The reductions had been expected since Boeing revealed plans last month to slash its global workforce by 10% - or roughly 16,000 jobs.
"I wish there were some other way," chief executive Dave Calhoun wrote in an email to staff.
Boeing has been reeling from a drop in demand for aircraft, as travel plunges amid the pandemic and worsens the pressures on the company, which was already in crisis following two fatal crashes of its 737 Max plane and the global grounding of the plane last year.
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